Homo sapiens Protein: KIF21A | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-26840.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | KIF21A | ||||||||||||||||||
Protein Name | kinesin family member 21A | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000354878 | ||||||||||||||||||
InnateDB Gene | IDBG-26836 (KIF21A) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity (By similarity). {ECO:0000250}. | ||||||||||||||||||
Subcellular Localization | Cytoplasm, cytoskeleton {ECO:0000305}. | ||||||||||||||||||
Disease Associations | Congenital fibrosis of extraocular muscles 1 (CFEOM1) [MIM:135700]: A congenital ocular motility disorder marked by restrictive ophthalmoplegia affecting extraocular muscles innervated by the oculomotor and/or trochlear nerves. It is clinically characterized by anchoring of the eyes in downward gaze, ptosis, and backward tilt of the head. Patients affected by congenital fibrosis of extraocular muscles type 1 show an absence of the superior division of the oculomotor nerve (cranial nerve III) and corresponding oculomotor subnuclei. {ECO:0000269PubMed:14595441, ECO:0000269PubMed:16157808}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||
Tissue Specificity | |||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR001680
WD40 repeat IPR001752 Kinesin, motor domain IPR009053 Prefoldin IPR016024 Armadillo-type fold IPR017986 WD40-repeat-containing domain IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF00400
PF00225 |
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PRINTS |
PR00380
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PIRSF | |||||||||||||||||||
SMART |
SM00320
SM00129 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q7Z4S6 | ||||||||||||||||||
PhosphoSite | PhosphoSite-Q7Z4S6 | ||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 55605 | ||||||||||||||||||
UniGene | Hs.374201 | ||||||||||||||||||
RefSeq | NP_001166935 | ||||||||||||||||||
HUGO | HGNC:19349 | ||||||||||||||||||
OMIM | 608283 | ||||||||||||||||||
CCDS | CCDS53776 | ||||||||||||||||||
HPRD | 10506 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AB051495 AB290166 AC084373 AC090668 AC121334 AF155117 AF450487 AK000059 AM177179 AY368076 BC041430 BC047572 BC136414 BX537855 CH471111 | ||||||||||||||||||
GenPept | AAD42883 AAH41430 AAH47572 AAI36415 AAP97680 AAR04774 BAA90916 BAB21799 BAG06720 CAD97863 CAJ45483 EAW57803 | ||||||||||||||||||