InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdc42ep4

Summary

InnateDB Protein

IDBP-268402.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc42ep4

Protein Name

CDC42 effector protein (Rho GTPase binding) 4

Synonyms

1500041M20Rik; Borg4; CEP4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102227

InnateDB Gene

IDBG-214075 (Cdc42ep4)

Protein Structure

UniProt Annotation

Function

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts.

Subcellular Localization

Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:11185749}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0007266	Rho protein signal transduction
GO:0008360	regulation of cell shape
GO:0031274	positive regulation of pseudopodium assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton
GO:0016020	membrane