Version 5.4
Mus musculus Gene: Cdc42ep4
Summary
InnateDB Gene IDBG-214075.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc42ep4
Gene Name CDC42 effector protein (Rho GTPase binding) 4
Synonyms 1500041M20Rik; Borg4; CEP4
Species Mus musculus
Ensembl Gene ENSMUSG00000041598
Encoded Proteins
IDBP-214077
CDC42 effector protein (Rho GTPase binding) 4
IDBP-268402
CDC42 effector protein (Rho GTPase binding) 4
IDBP-534417
CDC42 effector protein (Rho GTPase binding) 4
IDBP-539084
CDC42 effector protein (Rho GTPase binding) 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179604:
The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:113726850-113751881
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000053536 ENSMUSP00000060227
ENSMUST00000106616 ENSMUSP00000102227
ENSMUST00000131488 ENSMUSP00000114599
ENSMUST00000153453 ENSMUSP00000120316
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007266 Rho protein signal transduction
GO:0008360 regulation of cell shape
GO:0031274 positive regulation of pseudopodium assembly
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0012505 endomembrane system
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000179604
View Gene Order
ENSBTAG00000019115
Not yet available
Cross-References
SwissProt
TrEMBL A2A6Q3
UniProt Splice Variant
Entrez Gene 56699
UniGene Mm.293378
RefSeq NM_001163346 NM_020006 XM_006533815 XM_006533816 XM_006533817 XM_006533818
OMIM
CCDS CCDS25604
HPRD
IMGT
MGI ID MGI:1929760
MGI Symbol Cdc42ep4
EMBL AL603706
GenPept
RNA Seq Atlas 56699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca