InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prmt6

Summary

InnateDB Protein

IDBP-268499.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prmt6

Protein Name

protein arginine N-methyltransferase 6

Synonyms

AW124876; BB233495; Hrmt1l6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102177

InnateDB Gene

IDBG-188720 (Prmt6)

Protein Structure

UniProt Annotation

Function

Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence. Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. {ECO:0000269PubMed:22904064, ECO:0000269PubMed:24570487}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0008276	protein methyltransferase activity
GO:0008469	histone-arginine N-methyltransferase activity
GO:0016740	transferase activity
GO:0035241	protein-arginine omega-N monomethyltransferase activity
GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054	histone methyltransferase activity
GO:0042393	histone binding
GO:0044020	histone methyltransferase activity (H4-R3 specific)
GO:0070611	histone methyltransferase activity (H3-R2 specific)
GO:0070612	histone methyltransferase activity (H2A-R3 specific)

Biological Process

GO:0006281	DNA repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006479	protein methylation
GO:0008152	metabolic process
GO:0016571	histone methylation
GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0034969	histone arginine methylation
GO:0034970	histone H3-R2 methylation
GO:0043985	histone H4-R3 methylation
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:2139971

InterPro

IPR003402 tRNA transferase Trm5/Tyw2
IPR007848 Methyltransferase small domain
IPR010456 Ribosomal L11 methyltransferase, PrmA
IPR013216 Methyltransferase type 11
IPR025799 Protein arginine N-methyltransferase
IPR027555 tRNA (mo5U34)-methyltransferase-like
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF02475
PF05175
PF06325
PF08241
PF05185
PF08003

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q6NZB1

PhosphoSite