Version 5.4
Mus musculus Gene: Prmt6
Summary
InnateDB Gene IDBG-188720.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prmt6
Gene Name protein arginine N-methyltransferase 6
Synonyms AW124876; BB233495; Hrmt1l6
Species Mus musculus
Ensembl Gene ENSMUSG00000049300
Encoded Proteins
IDBP-268499
protein arginine N-methyltransferase 6
IDBP-620051
protein arginine N-methyltransferase 6
IDBP-788160
protein arginine N-methyltransferase 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198890:
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:110246109-110250998
Strand Reverse strand
Band F3
Transcripts
ENSMUST00000106567 ENSMUSP00000102177
ENSMUST00000168412 ENSMUSP00000129801
ENSMUST00000190378 ENSMUSP00000140836
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008469 histone-arginine N-methyltransferase activity
GO:0016740 transferase activity
GO:0035241 protein-arginine omega-N monomethyltransferase activity
GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity
GO:0042054 histone methyltransferase activity
GO:0042393 histone binding
GO:0044020 histone methyltransferase activity (H4-R3 specific)
GO:0070611 histone methyltransferase activity (H3-R2 specific)
GO:0070612 histone methyltransferase activity (H2A-R3 specific)
Biological Process
GO:0006281 DNA repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0008152 metabolic process
GO:0016571 histone methylation
GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:0034969 histone arginine methylation
GO:0034970 histone H3-R2 methylation
GO:0043985 histone H4-R3 methylation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198890
View Gene Order
ENSBTAG00000039951
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_202766
Chromatin modifying enzymes pathway
REACT_244207
RMTs methylate histone arginines pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
REACT_207632
Chromatin organization pathway
REACT_243659
RMTs methylate histone arginines pathway
REACT_227044
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q6NZB1
TrEMBL
UniProt Splice Variant
Entrez Gene 99890
UniGene Mm.36115 Mm.398152 Mm.416004
RefSeq NM_178891
OMIM
CCDS CCDS38605
HPRD
IMGT
MGI ID MGI:2139971
MGI Symbol Prmt6
EMBL AK034732 AK087551 AK172003 AK172105 AK172722 BC022899 BC066221
GenPept AAH22899 AAH66221 BAC28811 BAC39923 BAE42769 BAE42828 BAE43144
RNA Seq Atlas 99890

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca