Version 5.4
Mus musculus Protein: Cd300lf
Summary
InnateDB Protein IDBP-268509.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd300lf
Protein Name CD300 antigen like family member F
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000102171
InnateDB Gene IDBG-214212 (Cd300lf)
Protein Structure
UniProt Annotation
Function Acts as an inhibitory receptor for myeloid cells and mast cells. Inhibits osteoclast formation. Induces macrophage cell death upon engagement. {ECO:0000269PubMed:14662855, ECO:0000269PubMed:17438331, ECO:0000269PubMed:18097021}.
Subcellular Localization Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in myeloid cells. Present on the surface of macrophages (at protein level). {ECO:0000269PubMed:14662855, ECO:0000269PubMed:18097021}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030316 osteoclast differentiation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2442359
InterPro IPR003599 Immunoglobulin subtype
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6SJQ7
PhosphoSite PhosphoSite-Q6SJQ7
TrEMBL
UniProt Splice Variant
Entrez Gene 246746
UniGene Mm.277387
RefSeq NP_001162624
MGI ID 1ZOX
MGI Symbol Cd300lf
OMIM
CCDS CCDS48980
HPRD
IMGT
EMBL AB292061 AF251703 AL606487 AY457047 BC057864
GenPept AAH57864 AAM19096 AAR27938 CAM21607 CAM21609

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca