Version 5.4
Mus musculus Gene: Cd300lf
Summary
InnateDB Gene IDBG-214212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd300lf
Gene Name CD300 antigen like family member F
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000047798
Encoded Proteins
IDBP-214214
CD300 antigen like family member F
IDBP-268507
CD300 antigen like family member F
IDBP-268509
CD300 antigen like family member F
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22043923
Cd300lf inhibits Myd88 and/or TRIF-mediated TLR signalling pathway through the dual activation of Ptpn6 and Ptpn11. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 22043923
[Homo sapiens] CD300LF inhibits MYD88 and/or TRIF-mediated TLR signalling pathway through the dual activation of PTPN6 and PTPN11.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186074:
CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6; MIM 176883) or SHIP (INPP5D; MIM 601582) (Sui et al., 2004 [PubMed 15184070]; Alvarez-Errico et al., 2004 [PubMed 15549731]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:115116214-115133992
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000051264 ENSMUSP00000053983
ENSMUST00000106562 ENSMUSP00000102172
ENSMUST00000106561 ENSMUSP00000102171
ENSMUST00000146254
ENSMUST00000124083
ENSMUST00000127927
ENSMUST00000149335
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0030316 osteoclast differentiation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000186074
View Gene Order
Cross-References
SwissProt Q6SJQ7
TrEMBL
UniProt Splice Variant
Entrez Gene 246746
UniGene Mm.277387
RefSeq NM_145634 XM_006533339 NM_001169153 XM_006533338
OMIM
CCDS CCDS25619 CCDS48980
HPRD
IMGT
MGI ID MGI:2442359
MGI Symbol Cd300lf
EMBL AB292061 AF251703 AL606487 AY457047 BC057864
GenPept AAH57864 AAM19096 AAR27938 CAM21607 CAM21609
RNA Seq Atlas 246746

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca