InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grin2c

Summary

InnateDB Protein

IDBP-268532.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grin2c

Protein Name

glutamate receptor, ionotropic, NMDA2C (epsilon 3)

Synonyms

GluN2C; NMDAR2C; NR2C;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102164

InnateDB Gene

IDBG-214257 (Grin2c)

Protein Structure

UniProt Annotation

Function

NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005261	cation channel activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006810	transport
GO:0006812	cation transport
GO:0008104	protein localization
GO:0009611	response to wounding
GO:0033058	directional locomotion
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0042177	negative regulation of protein catabolic process
GO:0042391	regulation of membrane potential
GO:0050885	neuromuscular process controlling balance
GO:0060079	regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005737	cytoplasm
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:95822

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR001828 Extracellular ligand-binding receptor
IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF01094
PF10565
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt