InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tsen54

Summary

InnateDB Protein

IDBP-268678.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tsen54

Protein Name

tRNA splicing endonuclease 54 homolog (S. cerevisiae)

Synonyms

0610034P02Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102090

InnateDB Gene

IDBG-214357 (Tsen54)

Protein Structure

UniProt Annotation

Function

Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Note=May be transiently localized in the nucleolus. {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397	mRNA processing

Cellular Component

GO:0005575	cellular_component
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

MGI:1923515

InterPro

PFAM

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8C2A2

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

76265

UniGene

Mm.275438

RefSeq

MGI ID

MGI Symbol

Tsen54

OMIM

CCDS

HPRD

IMGT

EMBL

AK002758 AK089005 AL645852

GenPept

BAB22335 BAC40696 CAM21979 CAM21980