InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Itgb4

Summary

InnateDB Protein

IDBP-268701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgb4

Protein Name

integrin beta 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102068

InnateDB Gene

IDBG-214382 (Itgb4)

Protein Structure

UniProt Annotation

Function

Integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction, hemidesmosome {ECO:0000250}. Note=Colocalizes with DST at the leading edge of migrating keratinocytes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0006914	autophagy
GO:0007154	cell communication
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0009611	response to wounding
GO:0031581	hemidesmosome assembly
GO:0046847	filopodium assembly
GO:0048870	cell motility

Cellular Component

GO:0005604	basement membrane
GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030056	hemidesmosome
GO:0031252	cell leading edge
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:96613

InterPro

IPR002035 von Willebrand factor, type A
IPR002369 Integrin beta subunit, N-terminal
IPR003644 Na-Ca exchanger/integrin-beta4
IPR003961 Fibronectin, type III
IPR012013 Integrin beta-4 subunit
IPR012896 Integrin beta subunit, tail
IPR013111 EGF-like domain, extracellular
IPR015812 Integrin beta subunit
IPR016201 Plexin-like fold

PFAM