InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itgb4

Summary

InnateDB Gene

IDBG-214382.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itgb4

Gene Name

integrin beta 4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020758

Encoded Proteins

IDBP-214384

integrin beta 4

IDBP-214386

integrin beta 4

IDBP-268699

integrin beta 4

IDBP-268701

integrin beta 4

IDBP-268703

integrin beta 4

IDBP-622633

integrin beta 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:115974709-116008412

Strand

Forward strand

Band

Transcripts

ENSMUST00000021107	ENSMUSP00000021107
ENSMUST00000068981	ENSMUSP00000070811
ENSMUST00000106461	ENSMUSP00000102069
ENSMUST00000106460	ENSMUSP00000102068
ENSMUST00000106458	ENSMUSP00000102066
ENSMUST00000151691
ENSMUST00000150129
ENSMUST00000127523
ENSMUST00000130286
ENSMUST00000169928	ENSMUSP00000127604

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.

Predicted by orthology
Total	23 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0006914	autophagy
GO:0007154	cell communication
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007275	multicellular organismal development
GO:0009611	response to wounding
GO:0031581	hemidesmosome assembly
GO:0046847	filopodium assembly
GO:0048870	cell motility

Cellular Component

GO:0005604	basement membrane
GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009925	basal plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030056	hemidesmosome
GO:0031252	cell leading edge
GO:0043235	receptor complex
GO:0070062	extracellular vesicular exosome