InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ELF1

Summary

InnateDB Protein

IDBP-26872.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ELF1

Protein Name

E74-like factor 1 (ets domain transcription factor)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000239882

InnateDB Gene

IDBG-26868 (ELF1)

Protein Structure

UniProt Annotation

Function

Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer. {ECO:0000269PubMed:8756667}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis. {ECO:0000269PubMed:8756667, ECO:0000269PubMed:9524226}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	23 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050860	negative regulation of T cell receptor signaling pathway