Version 5.4
Homo sapiens Gene: ELF1
Summary
InnateDB Gene IDBG-26868.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELF1
Gene Name E74-like factor 1 (ets domain transcription factor)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000120690
Encoded Proteins
IDBP-26872
E74-like factor 1 (ets domain transcription factor)
IDBP-295031
E74-like factor 1 (ets domain transcription factor)
IDBP-365994
E74-like factor 1 (ets domain transcription factor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21867680
ELF1 transcription factor negatively regulates TOLLIP, a negative regulator of Toll-like receptor (TLR) signalling, in response to O-linked N-acetylglucosamine (O-GlcNAc) modification. In intestinal epithelial cells, insufficient O-GlcNAc modification prevents ELF1-mediated transcriptional repression and thereby suppresses TLR signalling via upregulated TOLLIP gene expression.
InnateDB Annotation from Orthologs
Summary
PMID 21867680
[Mus musculus] Elf1 transcription factor negatively regulates Tollip, a negative regulator of Toll-like receptor (TLR) signalling, in response to O-linked N-acetylglucosamine (O-GlcNAc) modification. In intestinal epithelial cells insufficient O-GlcNAc modification prevents Elf1-mediated transcriptional repression and thereby suppresses TLR signalling via upregulated Tollip gene expression. (Demonstrated in human)
Entrez Gene
Summary This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:40931920-41061440
Strand Reverse strand
Band q14.11
Transcripts
ENST00000239882 ENSP00000239882
ENST00000405737 ENSP00000384135
ENST00000442101 ENSP00000405580
ENST00000498824
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 23 [view]
Protein-DNA 8 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0030154 cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050860 negative regulation of T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036461
View Gene Order
ENSBTAG00000007356
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
ap1_pathway
AP-1 transcription factor network
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
il2_stat5pathway
IL2 signaling events mediated by STAT5
Cross-References
SwissProt
TrEMBL Q5T9E7
UniProt Splice Variant
Entrez Gene 1997
UniGene Hs.135646 Hs.595366
RefSeq NM_001145353 NM_172373 XM_005266276 XM_005266277
HUGO HGNC:3316
OMIM 189973
CCDS CCDS9374
HPRD 01808
IMGT
EMBL AL157877
GenPept
RNA Seq Atlas 1997

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca