InnateDB Protein
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IDBP-268741.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Unc13d
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Protein Name
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unc-13 homolog D (C. elegans)
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Synonyms
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2610108D09Rik; Jinx; mFLJ00067; Munc13-4;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000102058
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InnateDB Gene
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IDBG-214399 (Unc13d)
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Protein Structure
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Function |
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis (By similarity). Regulates Ca(2+)- dependent secretory lysosome exocytosis in mast cells. {ECO:0000250, ECO:0000269PubMed:18354201}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Late endosome {ECO:0000250}. Recycling endosome {ECO:0000250}. Lysosome {ECO:0000269PubMed:18354201}. Note=Colocalizes with cytotoxic granules at the plasma membrane. Localizes to endosomal exocytic vesicles. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Mast cells. {ECO:0000269PubMed:18354201}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1917700
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InterPro |
IPR000008
C2 domain
IPR019558
Mammalian uncoordinated homology 13, subgroup, domain 2
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PFAM |
PF00168
PF10540
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PRINTS |
PR00360
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PIRSF |
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SMART |
SM00239
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TIGRFAMs |
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Modification |
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SwissProt |
B2RUP2
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PhosphoSite |
PhosphoSite-B2RUP2
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TrEMBL |
A2A858
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UniProt Splice Variant |
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Entrez Gene |
70450
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UniGene |
Mm.259460
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RefSeq |
XP_006534253
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MGI ID |
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MGI Symbol |
Unc13d
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK220199
AL607108
BC141289
EF127645
EF127646
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GenPept |
AAI41290
ABO15439
ABO15440
BAD90124
CAM24043
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