Version 5.4
Mus musculus Protein: Arhgap17
Summary
InnateDB Protein IDBP-268749.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgap17
Protein Name Rho GTPase activating protein 17
Synonyms 5730403H17Rik; Nadrin; Nadrin2; Rich1; Wbp15;
Species Mus musculus
Ensembl Protein ENSMUSP00000102050
InnateDB Gene IDBG-209112 (Arhgap17)
Protein Structure
UniProt Annotation
Function Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1 (By similarity). {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Note=Associates with membranes and concentrates at sites of cell-cell contact. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017124 SH3 domain binding
Biological Process
GO:0007165 signal transduction
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005923 tight junction
Protein Structure and Domains
PDB ID MGI:1917747
InterPro IPR000198 Rho GTPase-activating protein domain
IPR004148 BAR domain
IPR008936 Rho GTPase activation protein
PFAM PF00620
PF03114
PRINTS
PIRSF
SMART SM00324
SM00721
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UIA2
PhosphoSite PhosphoSite-Q3UIA2
TrEMBL
UniProt Splice Variant
Entrez Gene 70497
UniGene Mm.472252
RefSeq NP_653112
MGI ID
MGI Symbol Arhgap17
OMIM
CCDS CCDS52389
HPRD
IMGT
EMBL AB060553 AB060554 AK036468 AK036617 AK147010 AK149986 AK152266 BC003259
GenPept AAH03259 BAB43862 BAB43863 BAC29443 BAC29508 BAE27604 BAE29214 BAE31084

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca