Version 5.4
Mus musculus Protein: Exoc7
Summary
InnateDB Protein IDBP-268806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Exoc7
Protein Name exocyst complex component 7
Synonyms Exo70; sec70;
Species Mus musculus
Ensembl Protein ENSMUSP00000102019
InnateDB Gene IDBG-214441 (Exoc7)
Protein Structure
UniProt Annotation
Function Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. In adipocytes, plays a crucial role in targeting SLC2A4 vesicle to the plasma membrane in response to insulin, perhaps directing the vesicle to the precise site of fusion. {ECO:0000269PubMed:12687004}.
Subcellular Localization Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Note=Translocates, as a preformed complex with SEC6 and SEC8, to the plasma membrane in response to insulin through the activation of ARHQ.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006887 exocytosis
GO:0008150 biological_process
GO:0015031 protein transport
Cellular Component
GO:0000145 exocyst
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0032584 growth cone membrane
GO:0034451 centriolar satellite
Protein Structure and Domains
PDB ID MGI:1859270
InterPro IPR004140 Exocyst complex protein Exo70
IPR016159 Cullin repeat-like-containing domain
PFAM PF03081
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35250
PhosphoSite PhosphoSite-O35250
TrEMBL Q69ZS4
UniProt Splice Variant
Entrez Gene 53413
UniGene Mm.470428
RefSeq NP_001156344
MGI ID 2PFT
MGI Symbol Exoc7
OMIM
CCDS CCDS48983
HPRD
IMGT
EMBL AF014461 AK087601 AK169928 AK173094 BC028927 CH466558
GenPept AAB69345 AAH28927 BAC39941 BAD32372 BAE41466 EDL34570

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca