InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tufm

Summary

InnateDB Protein

IDBP-268864.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tufm

Protein Name

Tu translation elongation factor, mitochondrial

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102000

InnateDB Gene

IDBG-209544 (Tufm)

Protein Structure

UniProt Annotation

Function

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 87 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	87 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003746	translation elongation factor activity
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006414	translational elongation
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane

Protein Structure and Domains

PDB ID

MGI:1923686

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR009000 Translation protein, beta-barrel domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03144

PRINTS

PR00315

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BFR5