Version 5.4
Homo sapiens Protein: CMPK2
Summary
InnateDB Protein IDBP-26893.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CMPK2
Protein Name cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000256722
InnateDB Gene IDBG-26891 (CMPK2)
Protein Structure
UniProt Annotation
Function May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269PubMed:17999954, ECO:0000269PubMed:23416111}.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:17999954}.
Disease Associations
Tissue Specificity Among all investigated tumors, leukemia cells show the most abundant expression. {ECO:0000269PubMed:17999954}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004127 cytidylate kinase activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0009041 uridylate kinase activity
GO:0033862 UMP kinase activity
Biological Process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR014505 UMP-CMP kinase, mitochondrai
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM
PRINTS
PIRSF PIRSF019736
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5EBM0
PhosphoSite PhosphoSite-
TrEMBL I1Z9C7
UniProt Splice Variant
Entrez Gene 129607
UniGene Hs.7155
RefSeq NP_997198
HUGO HGNC:27015
OMIM 611787
CCDS CCDS42648
HPRD 11233
IMGT
EMBL AK127983 BC016969 BC089425 BC132821 BC141802 BC144202 JQ412833
GenPept AAH16969 AAH89425 AAI32822 AAI41803 AAI44203 AFJ19138 BAC87217

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca