Version 5.4
Homo sapiens Gene: CMPK2
Summary
InnateDB Gene IDBG-26891.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CMPK2
Gene Name cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134326
Encoded Proteins
IDBP-26893
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
IDBP-292700
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
IDBP-362367
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:6840570-6866635
Strand Reverse strand
Band p25.2
Transcripts
ENST00000256722 ENSP00000256722
ENST00000404168 ENSP00000384915
ENST00000458098 ENSP00000396385
ENST00000478738
ENST00000491738
ENST00000465619
ENST00000470479
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004127 cytidylate kinase activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0004798 thymidylate kinase activity
GO:0005524 ATP binding
GO:0009041 uridylate kinase activity
GO:0033862 UMP kinase activity
Biological Process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006227 dUDP biosynthetic process
GO:0006233 dTDP biosynthetic process
GO:0009142 nucleoside triphosphate biosynthetic process
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020638
View Gene Order
ENSBTAG00000019979
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00240
Pyrimidine metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.598628 Hs.7155
RefSeq NM_001256477 NM_001256478 NM_207315
HUGO
OMIM
CCDS CCDS42648 CCDS58695 CCDS58696
HPRD 11233
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca