InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sept1

Summary

InnateDB Protein

IDBP-269021.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sept1

Protein Name

septin 1

Synonyms

Diff6; Pnutl3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101921

InnateDB Gene

IDBG-210090 (Sept1)

Protein Structure

UniProt Annotation

Function

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). {ECO:0000250, ECO:0000305}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Midbody {ECO:0000250}. Note=Remains at the centrosomes and the nearby microtubules throughout mitosis. Localizes to the midbody during cytokinesis (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0007049	cell cycle
GO:0051301	cell division

Cellular Component

GO:0005815	microtubule organizing center
GO:0030496	midbody
GO:0031105	septin complex

Protein Structure and Domains

PDB ID

MGI:1858916

InterPro

IPR000038 Cell division protein GTP binding
IPR004881 Ribosome biogenesis GTPase RsgA, putative
IPR016491 Septin
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00735
PF03193

PRINTS

PIRSF

PIRSF006698

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P42209