Version 5.4
Mus musculus Protein: Rbfox3
Summary
InnateDB Protein IDBP-269099.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rbfox3
Protein Name RNA binding protein, fox-1 homolog (C. elegans) 3
Synonyms Fox-3; Hrnbp3; NeuN; Neuna60;
Species Mus musculus
Ensembl Protein ENSMUSP00000101885
InnateDB Gene IDBG-214655 (Rbfox3)
Protein Structure
UniProt Annotation
Function RNA-binding protein that regulates alternative splicing events. Regulates alternative splicing of RBFOX2 to enhance the production of mRNA species that are targeted for nonsense-mediated decay (NMD). {ECO:0000269PubMed:19713214, ECO:0000269PubMed:21747913}.
Subcellular Localization Nucleus. Cytoplasm.Isoform 1: Nucleus.Isoform 4: Cytoplasm.Isoform 5: Nucleus.
Disease Associations
Tissue Specificity Widely expressed in brain, regions including cerebral cortex, hippocampus, thalamus, caudate/putamen, cerebellum, as well as in the spinal cord (at protein level). Not expressed in all neuronal cells within a region, in cerebellum, expression is absent in Purkinje cells (at protein level). Expressed in the retina in the ganglion cells and some cells in the inner nuclear layer, but absent from the photoreceptor cells and most cells in the inner nuclear layer (at protein level). {ECO:0000269PubMed:1483388, ECO:0000269PubMed:15605376, ECO:0000269PubMed:19713214, ECO:0000269PubMed:21747913}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043025 neuronal cell body
GO:0043204 perikaryon
Protein Structure and Domains
PDB ID MGI:106368
InterPro IPR000504 RNA recognition motif domain
IPR017325 RNA binding protein Fox-1
IPR025670 Fox-1 C-terminal domain
PFAM PF00076
PF12414
PRINTS
PIRSF PIRSF037932
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BIF2
PhosphoSite PhosphoSite-Q8BIF2
TrEMBL A2A4W9
UniProt Splice Variant
Entrez Gene 52897
UniGene Mm.341103
RefSeq NP_001020102
MGI ID
MGI Symbol Rbfox3
OMIM
CCDS CCDS25705
HPRD
IMGT
EMBL AK079086 AK160816 AL591075 AL591514 AL591544 BC054403 CH466558 FJ958310 FJ958311
GenPept AAH54403 ACY91937 ACY91938 BAC37531 BAE36031 CAM15760 CAM15761 CAM15762 CAX16099 CAX16100 EDL34674

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca