InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RSAD2

Summary

InnateDB Protein

IDBP-26914.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RSAD2

Protein Name

radical S-adenosyl methionine domain containing 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000371471

InnateDB Gene

IDBG-26912 (RSAD2)

Protein Structure

UniProt Annotation

Function

Interferon-inducible iron-sulfur (4FE-4S) cluster- binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. {ECO:0000269PubMed:11752458, ECO:0000269PubMed:16108059, ECO:0000269PubMed:16982913, ECO:0000269PubMed:17686841, ECO:0000269PubMed:18005719, ECO:0000269PubMed:19074433}.

Subcellular Localization

Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus {ECO:0000269PubMed:11752458, ECO:0000269PubMed:16982913}. Endoplasmic reticulum {ECO:0000269PubMed:11752458, ECO:0000269PubMed:16982913}. Lipid droplet {ECO:0000250}. Mitochondrion. Mitochondrion inner membrane. Mitochondrion outer membrane. Note=Infection with human cytomegalovirus (HCMV) causes relocation to the Golgi apparatus and to cytoplasmic vacuoles which also contain HCMV proteins glycoprotein B and pp28. Interaction with human cytomegalovirus/HHV-5 protein vMIA/UL37 results in its relocalization from the endoplasmic reticulum to the mitochondria.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	1 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0005515	protein binding
GO:0043621	protein self-association
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0001503	ossification
GO:0008152	metabolic process
GO:0009615	response to virus
GO:0016032	viral process
GO:0030278	regulation of ossification
GO:0034157	positive regulation of toll-like receptor 7 signaling pathway
GO:0034165	positive regulation of toll-like receptor 9 signaling pathway
GO:0035710	CD4-positive, alpha-beta T cell activation
GO:0043367	CD4-positive, alpha-beta T cell differentiation
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0050709	negative regulation of protein secretion
GO:0051607	defense response to virus
GO:2000553	positive regulation of T-helper 2 cell cytokine production

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005811	lipid particle