Version 5.4
Homo sapiens Gene: RSAD2
Summary
InnateDB Gene IDBG-26912.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RSAD2
Gene Name radical S-adenosyl methionine domain containing 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134321
Encoded Proteins
IDBP-26914
radical S-adenosyl methionine domain containing 2
IDBP-362375
radical S-adenosyl methionine domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20308629
RSAD2 (viperin) is an antiviral protein whose expression is highly upregulated during viral infections via IFN-dependent and/or IFN-independent pathways and an IRF1 mediated type I IFN independent mechanism of enhanced RSAD2 expression provides a redundant mechanism to protect cells from viral infections.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 2:6865806-6898239
Strand Forward strand
Band p25.2
Transcripts
ENST00000382040 ENSP00000371471
ENST00000442639 ENSP00000406427
ENST00000474872
ENST00000489749
ENST00000477834
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 1 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0043621 protein self-association
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0001503 ossification
GO:0008152 metabolic process
GO:0009615 response to virus
GO:0016032 viral process
GO:0030278 regulation of ossification
GO:0034157 positive regulation of toll-like receptor 7 signaling pathway
GO:0034165 positive regulation of toll-like receptor 9 signaling pathway
GO:0035710 CD4-positive, alpha-beta T cell activation
GO:0043367 CD4-positive, alpha-beta T cell differentiation
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0050709 negative regulation of protein secretion
GO:0051607 defense response to virus
GO:2000553 positive regulation of T-helper 2 cell cytokine production
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005811 lipid particle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020641
View Gene Order
ENSBTAG00000016061
Not yet available
Cross-References
SwissProt Q8WXG1
TrEMBL C9J674
UniProt Splice Variant
Entrez Gene 91543
UniGene Hs.17518
RefSeq NM_080657
HUGO HGNC:30908
OMIM 607810
CCDS CCDS1656
HPRD
IMGT
EMBL AC017076 AF026941 AF442151 BC017969 CH471053
GenPept AAH17969 AAL50053 AAY14802 EAX01034
RNA Seq Atlas 91543

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca