InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Card14

Summary

InnateDB Protein

IDBP-269163.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Card14

Protein Name

caspase recruitment domain family, member 14

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101857

InnateDB Gene

IDBG-214692 (Card14)

Protein Structure

UniProt Annotation

Function

Plays a role in signaling mediated by TRAF2, TRAF3 and TRAF6 and protects cells against apoptosis. Stimulates the phosphorylation of BCL10 (By similarity). Activates NF-kappa-B via BCL10 and IKK. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0050700	CARD domain binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006915	apoptotic process
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0042981	regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0051092	positive regulation of NF-kappaB transcription factor activity

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0016235	aggresome

Protein Structure and Domains

PDB ID

MGI:2386258

InterPro

IPR001315 CARD domain
IPR001478 PDZ domain
IPR008144 Guanylate kinase-like
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00619
PF00595
PF13180

PRINTS

PIRSF

SMART

SM00114
SM00228

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99KF0