Version 5.4
Mus musculus Gene: Card14
Summary
InnateDB Gene IDBG-214692.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Card14
Gene Name caspase recruitment domain family, member 14
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000013483
Encoded Proteins
IDBP-214694
caspase recruitment domain family, member 14
IDBP-269163
caspase recruitment domain family, member 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000141527:
This gene encodes a caspase recruitment domain-containing protein that is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. Members of this protein family are scaffold proteins that are involved in a diverse array of cellular processes including cellular adhesion, signal transduction and cell polarity control. This protein has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:119307768-119345375
Strand Forward strand
Band E2
Transcripts
ENSMUST00000053245 ENSMUSP00000053665
ENSMUST00000106250 ENSMUSP00000101857
ENSMUST00000147167
ENSMUST00000151052
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0050700 CARD domain binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0006915 apoptotic process
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016235 aggresome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000141527
View Gene Order
ENSBTAG00000015261
Not yet available
Cross-References
SwissProt Q99KF0
TrEMBL
UniProt Splice Variant
Entrez Gene 170720
UniGene Mm.130832
RefSeq NM_130886 XM_006532375 XM_006532376
OMIM
CCDS CCDS25715
HPRD
IMGT
MGI ID MGI:2386258
MGI Symbol Card14
EMBL AF363457 BC004692 BC029102
GenPept AAH04692 AAH29102 AAK60137
RNA Seq Atlas 170720

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca