InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Macf1

Summary

InnateDB Protein

IDBP-269189.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Macf1

Protein Name

microtubule-actin crosslinking factor 1

Synonyms

ABP620; Acf7; Aclp7; MACF; mKIAA0465; R74989;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101819

InnateDB Gene

IDBG-185419 (Macf1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003779	actin binding
GO:0003824	catalytic activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0016887	ATPase activity

Biological Process

GO:0001707	mesoderm formation
GO:0006200	ATP catabolic process
GO:0006620	posttranslational protein targeting to membrane
GO:0006928	cellular component movement
GO:0007050	cell cycle arrest
GO:0007163	establishment or maintenance of cell polarity
GO:0016055	Wnt signaling pathway
GO:0044237	cellular metabolic process

Cellular Component

GO:0005856	cytoskeleton
GO:0015629	actin cytoskeleton
GO:0015630	microtubule cytoskeleton

Protein Structure and Domains

PDB ID

MGI:108559

InterPro

IPR001101 Plectin repeat
IPR002017 Spectrin repeat
IPR002048 EF-hand domain
IPR003108 Growth-arrest-specific protein 2 domain
IPR010997 HRDC-like
IPR018159 Spectrin/alpha-actinin
IPR024930 Skp domain

PFAM

PF00681
PF00435
PF00036
PF13202
PF13405
PF02187

PRINTS

PIRSF

SMART

SM00250
SM00054
SM00243
SM00150

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite