Version 5.4
Mus musculus Gene: Macf1
Summary
InnateDB Gene IDBG-185419.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Macf1
Gene Name microtubule-actin crosslinking factor 1
Synonyms ABP620; Acf7; Aclp7; MACF; mKIAA0465; R74989
Species Mus musculus
Ensembl Gene ENSMUSG00000028649
Encoded Proteins
IDBP-185423
microtubule-actin crosslinking factor 1
IDBP-185425
microtubule-actin crosslinking factor 1
IDBP-185433
microtubule-actin crosslinking factor 1
IDBP-269183
microtubule-actin crosslinking factor 1
IDBP-269185
microtubule-actin crosslinking factor 1
IDBP-269189
microtubule-actin crosslinking factor 1
IDBP-531948
microtubule-actin crosslinking factor 1
IDBP-537345
microtubule-actin crosslinking factor 1
IDBP-538745
microtubule-actin crosslinking factor 1
IDBP-534124
microtubule-actin crosslinking factor 1
IDBP-536209
microtubule-actin crosslinking factor 1
IDBP-535177
microtubule-actin crosslinking factor 1
IDBP-533822
microtubule-actin crosslinking factor 1
IDBP-533434
microtubule-actin crosslinking factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127603:
The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:123349633-123684360
Strand Reverse strand
Band D2.2
Transcripts
ENSMUST00000084301 ENSMUSP00000081324
ENSMUST00000082108 ENSMUSP00000080755
ENSMUST00000097897 ENSMUSP00000095507
ENSMUST00000106224 ENSMUSP00000101831
ENSMUST00000106220 ENSMUSP00000101827
ENSMUST00000106213 ENSMUSP00000101819
ENSMUST00000123765 ENSMUSP00000119600
ENSMUST00000154824 ENSMUSP00000117188
ENSMUST00000134458 ENSMUSP00000119885
ENSMUST00000151346 ENSMUSP00000114568
ENSMUST00000149022 ENSMUSP00000116085
ENSMUST00000140596 ENSMUSP00000117433
ENSMUST00000125447
ENSMUST00000147030 ENSMUSP00000123246
ENSMUST00000147228 ENSMUSP00000115847
ENSMUST00000146000
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003779 actin binding
GO:0003824 catalytic activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0016887 ATPase activity
Biological Process
GO:0001707 mesoderm formation
GO:0006200 ATP catabolic process
GO:0006620 posttranslational protein targeting to membrane
GO:0006928 cellular component movement
GO:0007050 cell cycle arrest
GO:0007163 establishment or maintenance of cell polarity
GO:0016055 Wnt signaling pathway
GO:0032886 regulation of microtubule-based process
GO:0043001 Golgi to plasma membrane protein transport
GO:0044237 cellular metabolic process
Cellular Component
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0032587 ruffle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127603
View Gene Order
ENSBTAG00000021024
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.402299 Mm.466074 Mm.485351 Mm.487445
RefSeq NM_001199136 NM_001199137 XM_006502662 XM_006502663 XM_006502664 XM_006502665 XM_006502666 XM_006502667 XM_006502668 XM_006502669 XM_006502670 XM_006502671 XM_006502672 XM_006502673 XM_006502674 XM_006502675 XM_006502676 XM_006502677 XM_006502678 XM_006502680 XM_006502681 XM_006502682 XM_006502683
OMIM
CCDS CCDS57294 CCDS57295
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca