Mus musculus Gene: Macf1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-185419.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Macf1 | ||||||||||||||||||||||
Gene Name | microtubule-actin crosslinking factor 1 | ||||||||||||||||||||||
Synonyms | ABP620; Acf7; Aclp7; MACF; mKIAA0465; R74989 | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000028649 | ||||||||||||||||||||||
Encoded Proteins |
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
microtubule-actin crosslinking factor 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127603:
The protein encoded by this gene belongs to the plakin family of cytoskeletal linker proteins. This protein family forms bridges between different cytoskeletal elements through specialized modular domains. The encoded protein is one of the largest size proteins identified in human cytoskeletal proteins. It has functional actin and microtubule binding domains, and it appears to stabilize actin at sites where microtubules and microfilaments meet. It may function in microtubule dynamics to facilitate actin-microtubule interactions at the cell periphery and to couple the microtubule network to cellular junctions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 4:123349633-123684360 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | D2.2 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Mm.402299 Mm.466074 Mm.485351 Mm.487445 | ||||||||||||||||||||||
RefSeq | NM_001199136 NM_001199137 XM_006502662 XM_006502663 XM_006502664 XM_006502665 XM_006502666 XM_006502667 XM_006502668 XM_006502669 XM_006502670 XM_006502671 XM_006502672 XM_006502673 XM_006502674 XM_006502675 XM_006502676 XM_006502677 XM_006502678 XM_006502680 XM_006502681 XM_006502682 XM_006502683 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS57294 CCDS57295 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||