InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Baiap2

Summary

InnateDB Protein

IDBP-269199.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Baiap2

Protein Name

brain-specific angiogenesis inhibitor 1-associated protein 2

Synonyms

IRSp53; R75030;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101838

InnateDB Gene

IDBG-214732 (Baiap2)

Protein Structure

UniProt Annotation

Function

Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions. {ECO:0000269PubMed:17115031}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in liver, brain, olfactory bulb, brain cortex, caudate putamen, hypothalamus and cerebellum. {ECO:0000269PubMed:12006592}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding
GO:0042802	identical protein binding
GO:0070064	proline-rich region binding

Biological Process

GO:0007165	signal transduction
GO:0007266	Rho protein signal transduction
GO:0008360	regulation of cell shape
GO:0009617	response to bacterium
GO:0016358	dendrite development
GO:0032956	regulation of actin cytoskeleton organization
GO:0046847	filopodium assembly
GO:0048167	regulation of synaptic plasticity
GO:0051017	actin filament bundle assembly
GO:0051764	actin crosslink formation

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0030175	filopodium
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:2137336

InterPro

IPR001452 SH3 domain
IPR011511 Variant SH3 domain
IPR013606 IRSp53/MIM homology domain (IMD)

PFAM

PF00018
PF14604
PF07653
PF08397

PRINTS

PR00452

PIRSF

SMART

SM00326

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8BKX1

PhosphoSite

PhosphoSite-Q8BKX1

TrEMBL

UniProt Splice Variant

Entrez Gene

108100

UniGene

RefSeq

MGI ID

MGI Symbol

Baiap2

OMIM

CCDS

HPRD

IMGT

EMBL

AB105196 AF390178 AF390179 AK049469 BC006620 BC016411

GenPept

AAH06620 AAH16411 AAK68153 AAK81838 BAC33764 BAC65241 BAC65242