InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Baiap2

Summary

InnateDB Gene

IDBG-214732.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Baiap2

Gene Name

brain-specific angiogenesis inhibitor 1-associated protein 2

Synonyms

IRSp53; R75030

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025372

Encoded Proteins

IDBP-214734

brain-specific angiogenesis inhibitor 1-associated protein 2

IDBP-214736

brain-specific angiogenesis inhibitor 1-associated protein 2

IDBP-214738

brain-specific angiogenesis inhibitor 1-associated protein 2

IDBP-269197

brain-specific angiogenesis inhibitor 1-associated protein 2

IDBP-269199

brain-specific angiogenesis inhibitor 1-associated protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175866:
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:119942763-120006782

Strand

Forward strand

Band

Transcripts

ENSMUST00000103021	ENSMUSP00000099310
ENSMUST00000026436	ENSMUSP00000026436
ENSMUST00000075180	ENSMUSP00000074674
ENSMUST00000106233	ENSMUSP00000101840
ENSMUST00000106231	ENSMUSP00000101838
ENSMUST00000152523
ENSMUST00000146566
ENSMUST00000146960
ENSMUST00000131580

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding
GO:0042802	identical protein binding
GO:0070064	proline-rich region binding

Biological Process

GO:0007165	signal transduction
GO:0007266	Rho protein signal transduction
GO:0008360	regulation of cell shape
GO:0009617	response to bacterium
GO:0016358	dendrite development
GO:0032956	regulation of actin cytoskeleton organization
GO:0046847	filopodium assembly
GO:0048167	regulation of synaptic plasticity
GO:0051017	actin filament bundle assembly
GO:0051764	actin crosslink formation

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0030054	cell junction
GO:0030175	filopodium
GO:0043005	neuron projection
GO:0070062	extracellular vesicular exosome