InnateDB Protein
|
IDBP-269376.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Uros
|
Protein Name
|
uroporphyrinogen III synthase
|
Synonyms
|
AI415298; UROIIIS; Uros3;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000101752
|
InnateDB Gene
|
IDBG-211247 (Uros)
|
Protein Structure
|
|
Function |
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (By similarity). {ECO:0000250}.
|
Subcellular Localization |
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
|
Predicted by orthology |
Total |
3 [view]
|
|
|
Molecular Function |
|
Biological Process |
GO:0006779
|
porphyrin-containing compound biosynthetic process
|
GO:0006780
|
uroporphyrinogen III biosynthetic process
|
GO:0006782
|
protoporphyrinogen IX biosynthetic process
|
GO:0033014
|
tetrapyrrole biosynthetic process
|
GO:0046677
|
response to antibiotic
|
GO:0071243
|
cellular response to arsenic-containing substance
|
GO:0071418
|
cellular response to amine stimulus
|
|
Cellular Component |
|
PDB ID |
MGI:98917
|
InterPro |
IPR003754
Tetrapyrrole biosynthesis, uroporphyrinogen III synthase
|
PFAM |
PF02602
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
P51163
|
PhosphoSite |
PhosphoSite-P51163
|
TrEMBL |
Q9JLU5
|
UniProt Splice Variant |
|
Entrez Gene |
22276
|
UniGene |
Mm.407149
|
RefSeq |
|
MGI ID |
|
MGI Symbol |
Uros
|
OMIM |
|
CCDS |
CCDS21934
|
HPRD |
|
IMGT |
|
EMBL |
AC127348
AF133258
AK002971
AK148116
BC068161
CH466531
U04439
U16216
U18867
|
GenPept |
AAA74742
AAA79978
AAA81898
AAF29593
AAH68161
BAB22486
BAE28354
EDL17769
EDL17770
EDL17773
|
|
|