InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Uros

Summary

InnateDB Protein

IDBP-269378.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uros

Protein Name

uroporphyrinogen III synthase

Synonyms

AI415298; UROIIIS; Uros3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101751

InnateDB Gene

IDBG-211247 (Uros)

Protein Structure

UniProt Annotation

Function

Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004852	uroporphyrinogen-III synthase activity
GO:0048037	cofactor binding

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0006780	uroporphyrinogen III biosynthetic process
GO:0006782	protoporphyrinogen IX biosynthetic process
GO:0033014	tetrapyrrole biosynthetic process
GO:0046677	response to antibiotic
GO:0071243	cellular response to arsenic-containing substance
GO:0071418	cellular response to amine stimulus