InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ebf3

Summary

InnateDB Protein

IDBP-269433.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ebf3

Protein Name

early B-cell factor 3

Synonyms

3110018A08Rik; mKIAA4201; O/E-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101724

InnateDB Gene

IDBG-211411 (Ebf3)

Protein Structure

UniProt Annotation

Function

Transcriptional activator which recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in adult olfactory epithelium. In embryo, expressed in epithalamus, hypothalamus, throughout the brainstem and near the ventricular zones of mesencephalon, in rostral rhombencephalon, in vomeronasal organ, at high level in developing retina, developing spinal cord, at low level in dorsal root ganglia, trigeminal ganglia, glossopharyngeal nerve ganglia. Not expressed in developing inner eat.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0045893	positive regulation of transcription, DNA-templated

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:894289

InterPro

IPR002909 IPT domain
IPR014756 Immunoglobulin E-set

PFAM

PF01833

PRINTS

PIRSF

SMART

SM00429

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O08791

PhosphoSite

PhosphoSite-O08791

TrEMBL

UniProt Splice Variant

Entrez Gene

13593

UniGene

Mm.258708

RefSeq

NP_001106886

MGI ID

MGI Symbol

Ebf3

OMIM

CCDS

CCDS52422

HPRD

IMGT

EMBL

U82442 U92702 U92704

GenPept

AAB58322 AAB58324 AAC64323