InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bnip3

Summary

InnateDB Protein

IDBP-269446.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bnip3

Protein Name

BCL2/adenovirus E1B interacting protein 3

Synonyms

Nip3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101718

InnateDB Gene

IDBG-269444 (Bnip3)

Protein Structure

UniProt Annotation

Function

Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2 (By similarity). Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane may play a critical role in the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion. Mitochondrion outer membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity
GO:0051020	GTPase binding

Biological Process

GO:0001666	response to hypoxia
GO:0006309	apoptotic DNA fragmentation
GO:0006338	chromatin remodeling
GO:0006915	apoptotic process
GO:0008219	cell death
GO:0008626	granzyme-mediated apoptotic signaling pathway
GO:0010637	negative regulation of mitochondrial fusion
GO:0035694	mitochondrial protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043068	positive regulation of programmed cell death
GO:0043243	positive regulation of protein complex disassembly
GO:0043653	mitochondrial fragmentation involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045837	negative regulation of membrane potential
GO:0046902	regulation of mitochondrial membrane permeability
GO:0048102	autophagic cell death
GO:0050873	brown fat cell differentiation
GO:0051402	neuron apoptotic process
GO:0051607	defense response to virus
GO:0055093	response to hyperoxia
GO:0070301	cellular response to hydrogen peroxide
GO:0071260	cellular response to mechanical stimulus
GO:0071279	cellular response to cobalt ion
GO:0071456	cellular response to hypoxia
GO:0072593	reactive oxygen species metabolic process
GO:0090141	positive regulation of mitochondrial fission
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097345	mitochondrial outer membrane permeabilization
GO:1990144	intrinsic apoptotic signaling pathway in response to hypoxia

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0030425	dendrite
GO:0031307	integral component of mitochondrial outer membrane
GO:0031966	mitochondrial membrane