Version 5.4
Mus musculus Gene: Bnip3
Summary
InnateDB Gene IDBG-269444.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bnip3
Gene Name BCL2/adenovirus E1B interacting protein 3
Synonyms Nip3
Species Mus musculus
Ensembl Gene ENSMUSG00000078566
Encoded Proteins
IDBP-269446
BCL2/adenovirus E1B interacting protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 26253785
Mitophagy-inducing proteins Bnip3 and Bnip3l play a regulatory role in the generation of robust natural killer cell memory.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176171:
This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:138890836-138909519
Strand Reverse strand
Band F4
Transcripts
ENSMUST00000106112 ENSMUSP00000101718
ENSMUST00000130500
ENSMUST00000141223
ENSMUST00000148970
ENSMUST00000125359
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051020 GTPase binding
Biological Process
GO:0001666 response to hypoxia
GO:0006309 apoptotic DNA fragmentation
GO:0006338 chromatin remodeling
GO:0006915 apoptotic process
GO:0008219 cell death
GO:0008626 granzyme-mediated apoptotic signaling pathway
GO:0010637 negative regulation of mitochondrial fusion
GO:0035694 mitochondrial protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043243 positive regulation of protein complex disassembly
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045837 negative regulation of membrane potential
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048102 autophagic cell death
GO:0050873 brown fat cell differentiation
GO:0051402 neuron apoptotic process
GO:0051607 defense response to virus
GO:0055093 response to hyperoxia
GO:0070301 cellular response to hydrogen peroxide
GO:0071260 cellular response to mechanical stimulus
GO:0071279 cellular response to cobalt ion
GO:0071456 cellular response to hypoxia
GO:0072593 reactive oxygen species metabolic process
GO:0090141 positive regulation of mitochondrial fission
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097345 mitochondrial outer membrane permeabilization
GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0031307 integral component of mitochondrial outer membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000176171
View Gene Order
ENSBTAG00000017804
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt O55003
TrEMBL
UniProt Splice Variant
Entrez Gene 12176
UniGene Mm.378890
RefSeq NM_009760
OMIM
CCDS CCDS40168
HPRD
IMGT
MGI ID MGI:109326
MGI Symbol Bnip3
EMBL AF041054 AK014223 AK075943 AK152610 BC046603
GenPept AAD02922 AAH46603 BAB29214 BAC36072 BAE31356
RNA Seq Atlas 12176

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca