InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ifitm1

Summary

InnateDB Protein

IDBP-269593.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ifitm1

Protein Name

interferon induced transmembrane protein 1

Synonyms

1110036C17Rik; DSPA2a; Mil-2; Mil2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101655

InnateDB Gene

IDBG-211937 (Ifitm1)

Protein Structure

UniProt Annotation

Function

IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53- dependent manner. Acts as a positive regulator of osteoblast differentiation. {ECO:0000269PubMed:18505827, ECO:0000269PubMed:21253575}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:16326387}; Multi-pass membrane protein {ECO:0000269PubMed:16326387}.

Disease Associations

Tissue Specificity

Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells. {ECO:0000269PubMed:12659663}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0001503	ossification
GO:0001756	somitogenesis
GO:0008285	negative regulation of cell proliferation
GO:0009607	response to biotic stimulus
GO:0009615	response to virus
GO:0009952	anterior/posterior pattern specification
GO:0030336	negative regulation of cell migration
GO:0034341	response to interferon-gamma
GO:0035455	response to interferon-alpha
GO:0035456	response to interferon-beta
GO:0045071	negative regulation of viral genome replication
GO:0045669	positive regulation of osteoblast differentiation
GO:0046597	negative regulation of viral entry into host cell
GO:0051607	defense response to virus