InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RNF40

Summary

InnateDB Protein

IDBP-26966.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF40

Protein Name

ring finger protein 40

Synonyms

BRE1B; RBP95; STARING;

Species

Homo sapiens

Ensembl Protein

ENSP00000350563

InnateDB Gene

IDBG-26960 (RNF40)

Protein Structure

UniProt Annotation

Function

Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000269PubMed:16307923, ECO:0000269PubMed:19410543}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10944455}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine. {ECO:0000269PubMed:10944455}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.

Experimentally validated
Total	53 [view]
Protein-Protein	52 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0042803	protein homodimerization activity