InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HNRPDL

Summary

InnateDB Protein

IDBP-26973.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HNRPDL

Protein Name

heterogeneous nuclear ribonucleoprotein D-like

Synonyms

HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1; LGMD1G;

Species

Homo sapiens

Ensembl Protein

ENSP00000338552

InnateDB Gene

IDBG-26969 (HNRPDL)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence. {ECO:0000250, ECO:0000269PubMed:9538234}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a TNPO1-dependent manner.

Disease Associations

Tissue Specificity

Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Expressed in myeloid leukemia, gastric adenocarcinoma, cervical carcinoma, hepatoma, fibrosarcoma, colon adenocarcinoma, epidermoid carcinoma, osteosarcoma and urinary bladder carcinoma cells. {ECO:0000269PubMed:10072754, ECO:0000269PubMed:9538234}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.

Experimentally validated
Total	81 [view]
Protein-Protein	78 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0008143	poly(A) binding
GO:0034046	poly(G) binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006396	RNA processing
GO:0010468	regulation of gene expression