Version 5.4
Homo sapiens Gene: HNRPDL
Summary
InnateDB Gene IDBG-26969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRPDL
Gene Name heterogeneous nuclear ribonucleoprotein D-like
Synonyms HNRNP; HNRPDL; JKTBP; JKTBP2; laAUF1; LGMD1G
Species Homo sapiens
Ensembl Gene ENSG00000152795
Encoded Proteins
IDBP-26971
heterogeneous nuclear ribonucleoprotein D-like
IDBP-26973
heterogeneous nuclear ribonucleoprotein D-like
IDBP-484043
heterogeneous nuclear ribonucleoprotein D-like
IDBP-810113
heterogeneous nuclear ribonucleoprotein D-like
IDBP-810116
heterogeneous nuclear ribonucleoprotein D-like
IDBP-810114
heterogeneous nuclear ribonucleoprotein D-like
IDBP-810117
heterogeneous nuclear ribonucleoprotein D-like
IDBP-810118
heterogeneous nuclear ribonucleoprotein D-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:82422564-82430225
Strand Reverse strand
Band q21.22
Transcripts
ENST00000295470 ENSP00000295470
ENST00000349655 ENSP00000338552
ENST00000502762 ENSP00000422040
ENST00000507721 ENSP00000480156
ENST00000514511 ENSP00000478269
ENST00000602300 ENSP00000473677
ENST00000621267 ENSP00000483254
ENST00000614627 ENSP00000478723
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
Experimentally validated
Total 81 [view]
Protein-Protein 78 [view]
Protein-DNA 2 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003690 double-stranded DNA binding
GO:0003697 single-stranded DNA binding
GO:0008143 poly(A) binding
GO:0034046 poly(G) binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006396 RNA processing
GO:0010468 regulation of gene expression
Cellular Component
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029328
View Gene Order
ENSBTAG00000014804
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.656910 Hs.707013 Hs.707189 Hs.743490
RefSeq NM_001207000 NM_031372
HUGO
OMIM
CCDS CCDS3593 CCDS75153
HPRD 06185
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca