InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ins2

Summary

InnateDB Protein

IDBP-269823.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ins2

Protein Name

insulin II

Synonyms

AA986540; Ins-2; InsII; Mody; Mody4; proinsulin;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101554

InnateDB Gene

IDBG-212636 (Ins2)

Protein Structure

UniProt Annotation

Function

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005179	hormone activity
GO:0032403	protein complex binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000187	activation of MAPK activity
GO:0006006	glucose metabolic process
GO:0006983	ER overload response
GO:0007520	myoblast fusion
GO:0008286	insulin receptor signaling pathway
GO:0010468	regulation of gene expression
GO:0014902	myotube differentiation
GO:0015758	glucose transport
GO:0016042	lipid catabolic process
GO:0042325	regulation of phosphorylation
GO:0043393	regulation of protein binding
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0060070	canonical Wnt signaling pathway
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005732	small nucleolar ribonucleoprotein complex
GO:0005737	cytoplasm
GO:0030141	secretory granule
GO:0034774	secretory granule lumen