Mus musculus Gene: Ins2
Summary
InnateDB Gene IDBG-212636.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Ins2
Gene Name insulin II
Synonyms AA986540; Ins-2; InsII; Mody; Mody4; proinsulin;
Species Mus musculus
Ensembl Gene ENSMUSG00000000215
Encoded Proteins
insulin II
insulin II
insulin II
insulin II
insulin II
insulin II
insulin II
insulin II
Protein Structure
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000254647:
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:142678656-142699510
Strand Reverse strand
Band F5
Transcripts
ENSMUST00000000220 ENSMUSP00000000220
ENSMUST00000105934 ENSMUSP00000101554
ENSMUST00000105933 ENSMUSP00000101553
ENSMUST00000105932 ENSMUSP00000101552
ENSMUST00000105931 ENSMUSP00000101551
ENSMUST00000105930 ENSMUSP00000101550
ENSMUST00000125933 ENSMUSP00000115147
ENSMUST00000162317 ENSMUSP00000124643
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005179 hormone activity
GO:0032403 protein complex binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000187 activation of MAPK activity
GO:0006006 glucose metabolic process
GO:0006983 ER overload response
GO:0007520 myoblast fusion
GO:0008286 insulin receptor signaling pathway
GO:0010468 regulation of gene expression
GO:0014902 myotube differentiation
GO:0015758 glucose transport
GO:0016042 lipid catabolic process
GO:0042325 regulation of phosphorylation
GO:0042981 regulation of apoptotic process
GO:0043393 regulation of protein binding
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0060070 canonical Wnt receptor signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005732 small nucleolar ribonucleoprotein complex
GO:0005737 cytoplasm
GO:0030141 secretory granule
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Insulin receptor recycling pathway
Signal attenuation pathway
SHC activation pathway
IRS activation pathway
Signaling by Insulin receptor pathway
Insulin Processing pathway
Synthesis, Secretion, and Deacylation of Ghrelin pathway
Regulation of Insulin Secretion pathway
KEGG
Progesterone-mediated oocyte maturation pathway
Regulation of actin cytoskeleton pathway
MTOR signaling pathway pathway
Maturity onset diabetes of the young pathway
Type I diabetes mellitus pathway
Type II diabetes mellitus pathway
Regulation of autophagy pathway
Insulin signaling pathway pathway
Prostate cancer pathway
Aldosterone-regulated sodium reabsorption pathway
Oocyte meiosis pathway
INOH
Insulin receptor signaling pathway
GPCR signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Insulin receptor recycling pathway
Signal attenuation pathway
IRS activation pathway
SHC activation pathway
Signaling by Insulin receptor pathway
Insulin Processing pathway
Synthesis, Secretion, and Deacylation of Ghrelin pathway
Regulation of Insulin Secretion pathway
Regulation of gene expression in beta cells pathway
KEGG
Progesterone-mediated oocyte maturation pathway
Type I diabetes mellitus pathway
Insulin signaling pathway pathway
Prostate cancer pathway
Maturity onset diabetes of the young pathway
Type II diabetes mellitus pathway
Regulation of actin cytoskeleton pathway
MTOR signaling pathway pathway
Regulation of autophagy pathway
Aldosterone-regulated sodium reabsorption pathway
Oocyte meiosis pathway
INOH
GPCR signaling pathway
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Signaling events mediated by PTP1B
ATF-2 transcription factor network
Signaling events mediated by TCPTP
FOXA1 transcription factor network
Arf6 trafficking events
Insulin Pathway
Insulin-mediated glucose transport
Cross-References
SwissProt P01326
TrEMBL D0EY27 D3YWU5 D3Z595 D3Z596 E0CXX7 Q5EEX1
UniProt Splice Variant
Entrez Gene 16334
UniGene
RefSeq NM_001185083 NM_001185084 NM_008387
OMIM
CCDS CCDS22034
HPRD
IMGT
MGI ID 96573 MGI:96573
MGI Symbol Ins2
EMBL AC013548 AK007612 AY899305 BC099934 BC132650 BC132652 BC145554 CH466531 GQ915612 X04724
GenPept AAH99934 AAI32651 AAI32653 AAI45555 AAW83742 ACX53313 BAB25135 CAA28433 EDL18179 EDL18180
ImmGen Ins2 (murine)
RNA Seq Atlas 16334