Version 5.4
| Mus musculus Protein: Gpr3 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-269871.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Gpr3 | ||||||||
| Protein Name | G-protein coupled receptor 3 | ||||||||
| Synonyms | Gpcr20; Gpcr21; Gpcr3; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000101531 | ||||||||
| InnateDB Gene | IDBG-194760 (Gpr3) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons (By similarity) and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes. {ECO:0000250, ECO:0000269PubMed:15956199, ECO:0000269PubMed:19259266}. | ||||||||
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in both the forebrain and hindbrain, with the highest level in habenula. Lower level expression in the testis. Highly expressed in regions. {ECO:0000269PubMed:19259266, ECO:0000269PubMed:8262253}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | MGI:101908 | ||||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR000723 G protein-coupled receptor 3/6/12 orphan IPR000984 G protein-coupled receptor 3 IPR017452 GPCR, rhodopsin-like, 7TM |
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| PFAM |
PF00001
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| PRINTS |
PR00237
PR00644 PR00648 |
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| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | P35413 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | B1AUM8 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 14748 | ||||||||
| UniGene | Mm.4721 | ||||||||
| RefSeq | |||||||||
| MGI ID | |||||||||
| MGI Symbol | Gpr3 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS18743 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AK140302 AK140464 AK158917 AL671858 BC138248 BC138250 CH466552 D21062 | ||||||||
| GenPept | AAI38249 AAI38251 BAA04641 BAE24325 BAE24399 BAE34727 CAM21563 EDL30077 | ||||||||