InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pafah2

Summary

InnateDB Protein

IDBP-269956.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pafah2

Protein Name

platelet-activating factor acetylhydrolase 2

Synonyms

2310074E22Rik; AI507170;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101495

InnateDB Gene

IDBG-196236 (Pafah2)

Protein Structure

UniProt Annotation

Function

Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0008236	serine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0016042	lipid catabolic process
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:2140321

InterPro

IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
IPR005065 Platelet-activating factor acetylhydrolase
IPR016715 Platelet-activating factor acetylhydrolase, eucaryote
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00326
PF03403

PRINTS

PIRSF

PIRSF018169

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8VDG7