Version 5.4
Mus musculus Gene: Pafah2
Summary
InnateDB Gene IDBG-196236.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pafah2
Gene Name platelet-activating factor acetylhydrolase 2
Synonyms 2310074E22Rik; AI507170
Species Mus musculus
Ensembl Gene ENSMUSG00000037366
Encoded Proteins
IDBP-269954
platelet-activating factor acetylhydrolase 2
IDBP-269956
platelet-activating factor acetylhydrolase 2
IDBP-535442
platelet-activating factor acetylhydrolase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158006:
This gene encodes platelet-activating factor acetylhydrolase isoform 2, a single-subunit intracellular enzyme that catalyzes the removal of the acetyl group at the SN-2 position of platelet-activating factor (identified as 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine). However, this lipase exhibits a broader substrate specificity than simply platelet activating factor. Two other isoforms of intracellular platelet-activating factor acetylhydrolase exist, and both are multi-subunit enzymes. Additionally, there is a single-subunit serum isoform of this enzyme. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:134396320-134427413
Strand Forward strand
Band D3
Transcripts
ENSMUST00000105870 ENSMUSP00000101496
ENSMUST00000105869 ENSMUSP00000101495
ENSMUST00000140888
ENSMUST00000131337
ENSMUST00000148863
ENSMUST00000132658 ENSMUSP00000117607
ENSMUST00000145626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016042 lipid catabolic process
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000158006
View Gene Order
ENSBTAG00000005105
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00565
Ether lipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00565
Ether lipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.22116
RefSeq NM_001285872 NM_001285874 NM_001285877 NM_133880 XM_006538454 XM_006538455
OMIM
CCDS CCDS18771 CCDS71490
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca