InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stmn1

Summary

InnateDB Protein

IDBP-269958.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stmn1

Protein Name

stathmin 1

Synonyms

19k; Lag; Lap18; Op18; P18; P19; Pig; Pp17; Pp18; Pp19; Pr22; Smn;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101494

InnateDB Gene

IDBG-196306 (Stmn1)

Protein Structure

UniProt Annotation

Function

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis (By similarity). Involved in the control of the learned and innate fear. {ECO:0000250, ECO:0000269PubMed:16286011}.

Subcellular Localization

Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Highly expressed in the lateral nucleus of the amygdala. {ECO:0000269PubMed:16286011}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015631	tubulin binding

Biological Process

GO:0007019	microtubule depolymerization
GO:0007052	mitotic spindle organization
GO:0007409	axonogenesis
GO:0009615	response to virus
GO:0031110	regulation of microtubule polymerization or depolymerization
GO:0031115	negative regulation of microtubule polymerization
GO:0051272	positive regulation of cellular component movement