InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kdm1a

Summary

InnateDB Protein

IDBP-270001.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Kdm1a

Protein Name

lysine (K)-specific demethylase 1A

Synonyms

1810043O07Rik; AA408884; Aof2; D4Ertd478e; Kdm1; Lsd1; mKIAA0601;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101473

InnateDB Gene

IDBG-198084 (Kdm1a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 98 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	98 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0006355	regulation of transcription, DNA-templated
GO:0008283	cell proliferation
GO:0021983	pituitary gland development
GO:0034720	histone H3-K4 demethylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046886	positive regulation of hormone biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Protein Structure and Domains

PDB ID

MGI:1196256

InterPro

IPR001327 Pyridine nucleotide-disulphide oxidoreductase, NAD-binding domain
IPR002937 Amine oxidase
IPR003953 FAD binding domain
IPR006076 FAD dependent oxidoreductase
IPR007526 SWIRM domain
IPR009057 Homeodomain-like
IPR017366 Histone lysine-specific demethylase

PFAM

PF00070
PF01593
PF00890
PF01266
PF04433

PRINTS

PIRSF

PIRSF038051

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite