InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ephb2

Summary

InnateDB Protein

IDBP-270003.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ephb2

Protein Name

Eph receptor B2

Synonyms

Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5; Qek5; Sek3; Tyro5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101472

InnateDB Gene

IDBG-198182 (Ephb2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005003	ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008046	axon guidance receptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000902	cell morphogenesis
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007411	axon guidance
GO:0007612	learning
GO:0009887	organ morphogenesis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021631	optic nerve morphogenesis
GO:0021952	central nervous system projection neuron axonogenesis
GO:0031290	retinal ganglion cell axon guidance
GO:0048013	ephrin receptor signaling pathway
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048170	positive regulation of long-term neuronal synaptic plasticity
GO:0048593	camera-type eye morphogenesis
GO:0050770	regulation of axonogenesis
GO:0050771	negative regulation of axonogenesis

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:99611

InterPro

IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
IPR013761 Sterile alpha motif/pointed domain
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1

PFAM

PF00069
PF01404
PF07714
PF00041
PF01108
PF07647
PF07699
PF00536

PRINTS

PR00109

PIRSF

PIRSF000666

SMART

SM00615
SM00454
SM00220
SM00060
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A3KG00

UniProt Splice Variant

Entrez Gene

13844

UniGene

Mm.463720

RefSeq

MGI ID

MGI Symbol

Ephb2

OMIM

CCDS

HPRD

IMGT

EMBL

AL627214 AL627345 AL671173

GenPept