InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spen

Summary

InnateDB Protein

IDBP-270128.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spen

Protein Name

SPEN homolog, transcriptional regulator (Drosophila)

Synonyms

Mint; mKIAA0929;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101412

InnateDB Gene

IDBG-202178 (Spen)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001085	RNA polymerase II transcription factor binding
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003676	nucleic acid binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050769	positive regulation of neurogenesis

Cellular Component

GO:0005634	nucleus
GO:0017053	transcriptional repressor complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1891706

InterPro

IPR000504 RNA recognition motif domain
IPR010912 Spen paralogue/orthologue C-terminal, metazoa
IPR012921 Spen paralogue and orthologue SPOC, C-terminal
IPR016194 SPOC like C-terminal domain

PFAM

PF00076
PF07744

PRINTS

PIRSF

SMART

SM00360

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite