InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Spen

Summary

InnateDB Gene

IDBG-202178.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spen

Gene Name

SPEN homolog, transcriptional regulator (Drosophila)

Synonyms

Mint; mKIAA0929

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040761

Encoded Proteins

IDBP-202180

SPEN homolog, transcriptional regulator (Drosophila)

IDBP-270128

SPEN homolog, transcriptional regulator (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000065526:
This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:141467890-141538597

Strand

Reverse strand

Band

Transcripts

ENSMUST00000078886	ENSMUSP00000077925
ENSMUST00000105786	ENSMUSP00000101412
ENSMUST00000147227
ENSMUST00000152411
ENSMUST00000144500
ENSMUST00000152081

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001085	RNA polymerase II transcription factor binding
GO:0001191	RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
GO:0003676	nucleic acid binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050769	positive regulation of neurogenesis

Cellular Component

GO:0005634	nucleus
GO:0017053	transcriptional repressor complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000065526

View Gene Order

ENSBTAG00000018729

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_3

Notch pathway

REACTOME

KEGG

INOH

PID NCI

hes_heypathway

Notch-mediated HES/HEY network

notch_pathway

Notch signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.299906

RefSeq

NM_019763 XM_006539069 XM_006539070 XM_006539071

OMIM

CCDS

CCDS38940

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas