InnateDB Protein
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IDBP-270130.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Fblim1
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Protein Name
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filamin binding LIM protein 1
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Synonyms
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2410043F08Rik; Cal; Fblp1; Gt10; migfilin; migfilin(s);
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000101411
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InnateDB Gene
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IDBG-202206 (Fblim1)
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Protein Structure
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Function |
Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1921452
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InterPro |
IPR001781
Zinc finger, LIM-type
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PFAM |
PF00412
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PRINTS |
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PIRSF |
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
Q71FD7
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PhosphoSite |
PhosphoSite-Q71FD7
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TrEMBL |
A2ADF4
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UniProt Splice Variant |
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Entrez Gene |
74202
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UniGene |
Mm.490327
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RefSeq |
NP_598515
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MGI ID |
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MGI Symbol |
Fblim1
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OMIM |
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CCDS |
CCDS18876
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HPRD |
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IMGT |
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EMBL |
AF513359
AK154680
AK170151
AK170440
AL670446
BC004777
CH466615
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GenPept |
AAH04777
AAQ08090
BAE32761
BAE41598
BAE41798
CAM19893
EDL13381
EDL13382
EDL13383
EDL13384
EDL13385
EDL13386
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