Version 5.4
Mus musculus Gene: Fblim1
Summary
InnateDB Gene IDBG-202206.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fblim1
Gene Name filamin binding LIM protein 1
Synonyms 2410043F08Rik; Cal; Fblp1; Gt10; migfilin; migfilin(s)
Species Mus musculus
Ensembl Gene ENSMUSG00000006219
Encoded Proteins
IDBP-202208
filamin binding LIM protein 1
IDBP-270130
filamin binding LIM protein 1
IDBP-270132
filamin binding LIM protein 1
IDBP-534214
filamin binding LIM protein 1
IDBP-535098
filamin binding LIM protein 1
IDBP-533402
filamin binding LIM protein 1
IDBP-536497
filamin binding LIM protein 1
IDBP-541616
filamin binding LIM protein 1
IDBP-537343
filamin binding LIM protein 1
IDBP-535232
filamin binding LIM protein 1
IDBP-540874
filamin binding LIM protein 1
IDBP-533115
filamin binding LIM protein 1
IDBP-541400
filamin binding LIM protein 1
IDBP-541613
filamin binding LIM protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162458:
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:141576062-141606096
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000006381 ENSMUSP00000006381
ENSMUST00000105785 ENSMUSP00000101411
ENSMUST00000105784 ENSMUSP00000101410
ENSMUST00000141518 ENSMUSP00000123669
ENSMUST00000153189 ENSMUSP00000123322
ENSMUST00000130181 ENSMUSP00000115992
ENSMUST00000147764 ENSMUSP00000120600
ENSMUST00000147785 ENSMUSP00000114313
ENSMUST00000137491
ENSMUST00000127455 ENSMUSP00000120028
ENSMUST00000129602 ENSMUSP00000118647
ENSMUST00000131317 ENSMUSP00000116395
ENSMUST00000123150 ENSMUSP00000121037
ENSMUST00000136831 ENSMUSP00000116596
ENSMUST00000133874 ENSMUSP00000116589
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0031005 filamin binding
Biological Process
GO:0008360 regulation of cell shape
GO:0016337 single organismal cell-cell adhesion
GO:0033623 regulation of integrin activation
Cellular Component
GO:0001725 stress fiber
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0030054 cell junction
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162458
View Gene Order
ENSBTAG00000018725
Not yet available
Pathways
NETPATH
REACTOME
REACT_243772
Cell-extracellular matrix interactions pathway
REACT_241978
Cell junction organization pathway
REACT_223082
Cell-Cell communication pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20649
Cell-extracellular matrix interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_214866
Cell junction organization pathway
REACT_206475
Cell-Cell communication pathway
REACT_213279
Cell-extracellular matrix interactions pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A2ADF1 A2ADF2 A2ADF3 A2ADF4
UniProt Splice Variant
Entrez Gene 74202
UniGene Mm.286536 Mm.416189 Mm.490327
RefSeq NM_001163256 NM_133754 XM_006539213 XM_006539214 XM_006539215 XM_006539216
OMIM
CCDS CCDS18876
HPRD
IMGT
MGI ID MGI:1921452
MGI Symbol Fblim1
EMBL AL670446
GenPept
RNA Seq Atlas 74202

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca